How many mg of tetracycline

Tetracycline-sensitive infections, including respiratory, genitourinary, skin and soft tissue, and those caused by rickettsiae and Mycoplasma pneumoniae ; also cholera, psittacosis, plague, shigellosis. Adult Dosage: Take with fluids, 1 hour before or 2 hours after meals. Children Dosage: Not recommended. Tetracycline Classification: Tetracycline antibiotic. Tetracycline Interactions: Avoid methoxyflurane, photosensitizing agents. Adverse Reactions: Photosensitivity, GI upset, rash, blood dyscrasias, increased BUN, hepatotoxicity; rare: esophagitis and esophageal ulceration.

How Supplied: Contact supplier. It was previously thought that antibiotics may decrease the effectiveness of OCs containing estrogens due to stimulation of metabolism or a reduction in enterohepatic circulation via changes in GI flora. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported.

It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. Antituberculous drugs e. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. Another review concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines, and penicillin derivatives.

These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified.

During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. Data regarding progestin-only contraceptives or for newer combined contraceptive deliveries e.

Dicloxacillin: Major Avoid the coadministration of tetracycline antibiotics with penicillins as tetracyclines may interfere with the bactericidal action of penicillins. Didanosine, ddI: Major Tetracyclines should not be administered simultaneously with didanosine, ddI chewable tablets or powder for oral solution. The buffering agents contained in didanosine tablets and powder reduce tetracycline absorption.

Administer oral doses of tetracycline antibiotics 1 hour before or 4 hours after didanosine tablet or powder administration. The delayed-release didanosine capsules do not contain a buffering agent and would not be expected to interact with tetracycline antibiotics. Dienogest; Estradiol valerate: Moderate It was previously thought that antibiotics may decrease the effectiveness of oral contraceptives containing estrogens due to stimulation of estrogen metabolism or a reduction in estrogen enterohepatic circulation via changes in GI flora.

One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with oral contraceptives OCs and antibiotics was reported. It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma levels of oral contraceptives.

Another review of the subject concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines and penicillin derivatives. Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.

Digoxin: Major Measure serum digoxin concentrations before initiating tetracyclines. DRPs have little cardiac activity due to poor cardiac receptor binding and rapid excretion. Certain antibiotics can reduce the activity of intestinal bacteria, which, in turn, may enhance digoxin bioavailability via decreased DRP formation and increased enterohepatic recycling of digoxin in some patients.

Digoxin toxicity has been reported in patients previously stabilized on digoxin who receive antibiotics that affect E. Other antibiotics that have activity against E. Drospirenone: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Drospirenone; Estetrol: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.

Drospirenone; Estradiol: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Drospirenone; Ethinyl Estradiol: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Drospirenone; Ethinyl Estradiol; Levomefolate: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.

Elagolix; Estradiol; Norethindrone acetate: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Estradiol Cypionate; Medroxyprogesterone: Moderate It was previously thought that antibiotics may decrease the effectiveness of oral contraceptives containing estrogens due to stimulation of estrogen metabolism or a reduction in estrogen enterohepatic circulation via changes in GI flora.

Estradiol: Moderate It was previously thought that antibiotics may decrease the effectiveness of oral contraceptives containing estrogens due to stimulation of estrogen metabolism or a reduction in estrogen enterohepatic circulation via changes in GI flora. Estradiol; Levonorgestrel: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Estradiol; Norethindrone: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.

Estradiol; Norgestimate: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Ethinyl Estradiol: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.

Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Ethinyl Estradiol; Norelgestromin: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.

Ethinyl Estradiol; Norethindrone Acetate: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Ethinyl Estradiol; Norgestrel: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.

Ethynodiol Diacetate; Ethinyl Estradiol: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Etonogestrel; Ethinyl Estradiol: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Ferric Maltol: Moderate Iron salts or products that contain iron can decrease the oral bioavailability of tetracyclines.

The ability of tetracyclines to chelate with divalent cations such as iron, however, varies depending on the particular antibiotic and when the antibiotic is administered with regard to the iron-containing product.

Doxycycline chelates more avidly with iron than other tetracyclines. This pharmacokinetic interaction with iron can be minimized by staggering the doses of the antibiotic and iron by as much as possible. Administering iron-containing products 4 to 6 hours before or 1 hour after the oral tetracycline antibiotic dose will minimize the risk of antibiotic failure due to poor bioavailability.

Food: Major Calcium salts that are present in foods and dairy products can form chelates with tetracycline and impair absorption. Major Iron salts that are present in foods and dairy products can form chelates with tetracycline and impair absorption.

Halobetasol; Tazarotene: Moderate The manufacturer states that tazarotene should be administered with caution in patients who are also taking drugs known to be photosensitizers, such as tetracyclines, as concomitant use may augment phototoxicity. Patients should take care and use proper techniques to limit sunlight and UV exposure of treated areas.

Heparin: Minor Tetracyclines may partially counteract the anticoagulant actions of heparin, according to the product labels. However, this interaction is not likely of clinical significance in most patients since heparin therapy is adjusted to the partial thromboplastin time aPTT and other clinical parameters of the patient.

Hetastarch; Dextrose; Electrolytes: Major Administration of oral magnesium-containing products with oral tetracycline antibiotics may form nonabsorbable complexes resulting in decreased absorption of tetracyclines. This can compromise therapeutic efficacy of the tetracycline agent.

Do not administer oral magnesium-containing laxatives, antacids, dietary supplements, or other drugs within1 to 3 hours of taking an oral tetracycline. Major Divalent or trivalent cations readily chelate with tetracycline antibiotics, forming insoluble compounds.

Insoluble Prussian Blue: Moderate The binding of Insoluble Prussian Blue to some orally administered therapeutic drugs and essential nutrients is possible. Iron Salts: Moderate Iron salts or products that contain iron can decrease the oral bioavailability of tetracyclines. Iron Sucrose, Sucroferric Oxyhydroxide: Moderate Divalent or trivalent cations readily chelate with tetracycline antibiotics, forming insoluble compounds.

The oral absorption of tetracyclines will be significantly reduced by orally administered compounds that contain iron salts. To minimize the potential for this interaction, administer tetracycline antibiotics at least 1 hour before oral iron sucrose, sucroferric oxyhydroxide. Iron: Moderate Iron salts or products that contain iron can decrease the oral bioavailability of tetracyclines. Isotretinoin: Major Avoid the concomitant use of isotretinoin and systemic tetracyclines due to the potential for increased cranial pressure and an increased risk of pseudotumor cerebri benign intracranial hypertension.

Pseudotumor cerebri has been reported with both systemic retinoid and tetracycline use alone. Early signs and symptoms include papilledema, headache, nausea, vomiting, and visual disturbances.

Lansoprazole; Amoxicillin; Clarithromycin: Major Avoid the coadministration of tetracycline antibiotics with penicillins as tetracyclines may interfere with the bactericidal action of penicillins. Lanthanum Carbonate: Major Oral compounds known to interact with antacids, like tetracyclines, should not be taken within 2 hours of dosing with lanthanum carbonate.

If these agents are used concomitantly, space the dosing intervals appropriately. Monitor serum concentrations and clinical condition.

Leuprolide; Norethindrone: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Levonorgestrel: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Levonorgestrel; Ethinyl Estradiol: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.

Levonorgestrel; Ethinyl Estradiol; Ferrous Bisglycinate: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.

Lithium: Major The interaction between lithium and tetracycline appears variable. Both lithium toxicity and reduction in lithium concentrations have been reported during concurrent administration of tetracycline. Use of an alternative antibiotic should be considered in patients receiving lithium; however, if concurrent use of tetracycline is necessary, close monitoring of lithium levels and clinical response is recommended. Lomitapide: Moderate Caution should be exercised when lomitapide is used with other medications known to have potential for hepatotoxicity, such as tetracyclines.

The effect of concomitant administration of lomitapide with other hepatotoxic medications is unknown. More frequent monitoring of liver-related tests may be warranted.

Magnesium Citrate: Major Administration of oral magnesium citrate solution with oral tetracycline antibiotics may form nonabsorbable complexes resulting in decreased absorption of tetracyclines. Do not administer oral magnesium citrate solution within 1 to 3 hours of taking an oral tetracycline.

Magnesium Hydroxide: Moderate Separate administration of tetracycline and antacids by 2 to 3 hours. Magnesium Salts: Major Administration of oral magnesium-containing products with oral tetracycline antibiotics may form nonabsorbable complexes resulting in decreased absorption of tetracyclines. Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate: Major Administer tetracyclines at least 2 hours before or 6 hours after administration of magnesium sulfate; potassium sulfate; sodium sulfate.

The absorption of tetracyclines may be reduced by chelation with magnesium sulfate. Magnesium: Major Administration of oral magnesium-containing products with oral tetracycline antibiotics may form nonabsorbable complexes resulting in decreased absorption of tetracyclines. Mestranol; Norethindrone: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.

Methotrexate: Moderate Oral antibiotics such as tetracyclines may decrease intestinal absorption of methotrexate or interfere with enterohepatic circulation by inhibiting bowel flora and suppressing metabolism of the drug by bacteria.

Tetracyclines may displace methotrexate from protein binding sites leading to increased methotrexate levels. A case report describes a patient who received oral doxycycline in combination with her eleventh course of high-dose methotrexate. Methotrexate serum concentrations indicated a prolonged half-life and the patient developed severe gastrointestinal toxicity and myelosuppression including neutropenic fever.

This resulted in two prolonged hospital stays and a delay in her next course of chemotherapy. If concurrent use is necessary, closely monitor patients for signs or symptoms of skin toxicity. Metoclopramide: Minor Metoclopramide can increase the rate or extent of absorption of tetracycline because of accelerated gastric emptying, which increases the contact time with the small bowel where this drug is absorbed.

Mipomersen: Moderate Caution should be exercised when mipomersen is used with other medications known to have potential for hepatotoxicity, such as tetracyclines. The effect of concomitant administration of mipomersen with other hepatotoxic medications is unknown.

Drug information provided by: IBM Micromedex. Do not give tetracyclines to infants or children 8 years of age and younger unless directed by your doctor. Tetracyclines may cause permanently discolored teeth and other problems in patients in these age groups.

Tetracyclines should be taken with a full glass 8 ounces of water to prevent irritation of the esophagus tube between the throat and stomach or stomach. In addition, most tetracyclines except doxycycline and minocycline are best taken on an empty stomach either 1 hour before or 2 hours after meals.

However, if this medicine upsets your stomach, your doctor may want you to take it with food. Do not take milk, milk formulas, or other dairy products within 1 to 2 hours of the time you take tetracyclines except doxycycline and minocycline by mouth.

They may keep this medicine from working properly. If this medicine has changed color or tastes or looks different, has become outdated old , or has been stored incorrectly too warm or too damp area or place , do not use it. To do so may cause serious side effects. Throw away the medicine. In case of overdosage, discontinue medication, treat symptomatically and institute supportive measures. Tetracycline is not dialyzable. Usual daily dose, 1 gram as mg b.

Higher doses such as mg q. For treatment of brucellosis, mg tetracycline q. For treatment of gonorrhea, the recommended dose is mg by mouth four times a day for seven days.

In cases of moderate to severe acne which, in the judgement of the clinician, require long-term treatment, the recommended initial dosage is 1 gram daily in divided doses. When improvement is noted, dosage should be gradually reduced to maintenance levels ranging from mg to mg daily. In some patients it may be possible to maintain adequate remission of lesions with alternate-day or intermittent therapy.

Tetracycline therapy of acne should augment the other standard measures known to be of value. Absorption of tetracycline is impaired by antacids containing aluminum, calcium or magnesium and preparations containing iron, zinc, or sodium bicarbonate. In the treatment of streptococcal infections, a therapeutic dose of tetracycline should be administered for at least ten days.

Uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydia trachomatis : mg, by mouth, four times a day for at least seven days. Dispense in a tight, light resistant container as defined in the USP, with a child-resistant closure as required.

Hyperpigmentation of the thyroid has been produced by members of the tetracycline class in the following species: in rats by oxytetracycline, doxycycline, minocycline, tetracycline PO4 and methacycline; in minipigs by doxycycline, minocycline, tetracycline PO4 and methacycline; in dogs by doxycycline and minocycline; in monkeys by minocycline. Minocycline, tetracycline PO4, methacycline, doxycycline, tetracycline base, oxytetracycline HCI and tetracycline HCI were goitrogenic in rats fed a low iodine diet.

This goitrogenic effect was accomplished by high radioactive iodine uptake. Administration of minocycline also produced a large goiter with high radioiodine uptake in rats fed a relatively high iodine diet. Treatment of various animal species with this class of drugs has also resulted in the induction of thyroid hyperplasia in the following: in rats and dogs minocycline , in chickens chlortetracycline and in rats and mice oxytetracycline.

Adrenal gland hyperplasia has been observed in goats and rats treated with oxytetracycline. DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use.

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For Oral Use Rx only To reduce the development of drug-resistant bacteria and maintain the effectiveness of tetracycline hydrochloride and other antibacterial drugs, tetracycline hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Microbiology Tetracyclines are primarily bacteriostatic and exert their antimicrobial effect by the inhibition of protein synthesis. Gram-negative Bacteria Neisseria gonorrhea Haemophilus ducreyi Haemophilus influenzae Yersinia pestis formerly Pasteurella pestis Francisella tularensis formerly Pasteurella tularensis Vibrio cholera formerly Vibrio comma Bartonella bacilliformis Brucella species Because many strains of the following groups of gram-negative microorganisms have been shown to be resistant to tetracyclines, culture and susceptibility testing are recommended: Escherichia coli Klebsiella species Enterobacter aerogenes Shigella species Acinetobacter species formerly Mima species and Herellea species Bacteroides species.

Gram-positive Bacteria Because many strains of the following groups of gram-positive microorganisms have been shown to be resistant to tetracycline, culture and susceptibility testing are recommended. Streptococcus pyogenes Streptococcus pneumoniae Enterococcus group Streptococcus faecalis and Streptococcus faecium Alpha-hemolytic Streptococci viridans group.

Other microorganisms Chlamydia psittaci Chlamydia trachomatis Ureaplasma urealyticum Borrelia recurrentis Treponema pallidum Treponema pertenue Clostridia species Fusobacterium fusiforme Actinomyces species Bacillus anthraxis Propionibacterium acnes Entamoeba species Balantidium coli.

Susceptibility Testing A tetracycline disk may be used to determine microbial susceptibility to drugs in the tetracycline class. Tetracycline is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the conditions listed below: Upper respiratory tract infections caused by Streptococcus pyogenes , Streptococcus pneumoniae and Hemophilus influenzae.

Note: Tetracycline should not be used for streptococcal disease unless the organism has been demonstrated to be susceptible.

Lower respiratory tract infections caused by Streptococcus pyogenes , Streptococcus pneumoniae , Mycoplasma pneumoniae Eaton agent, and Klebsiella sp. Skin and soft tissue infections caused by Streptococcus pyogenes , Staphylococcus aureaus.